Some of the drugs that can potentially interact with tadalafil include cimetidine, erythromycin, and high blood pressure medicines. Drug interactions with tadalafil can affect your blood pressure and change how your body metabolizes medicines, among other things. It is important to talk with your doctor about any tadalafil drug interactions that may apply to you.
Drug Interactions With Tadalafil: An Introduction
Tadalafil (Cialis®) can potentially interact with a number of other medications. Some possible drug reactions with tadalafil include:
- High blood pressure medicines
- Alcohol
- Alpha blockers for high blood pressure (BPH) or benign prostatic hyperplasia (BPH), such as doxazosin (Cardura®), prazosin (Minipress®), terazosin (Hytrin®), tamsulosinFlomax®), and alfuzosin (Uroxatral®)
- Ritonavir (Norvir®) or indinavir (Crixivan®)
- Antifungals such as ketoconazole (Nizoral®), fluconazole (Diflucan®), or itraconazole (Sporanox®)
- Erythromycin
- Grapefruit juice
- Nitrates (nitroglycerin is the most common type)
- Theophylline (Theo-24®, Uniphyll tablets®).
High Blood Pressure Medicines
Taking both tadalafil and certain high blood pressure medicines can decrease your blood pressure. Consult your healthcare provider prior to taking tadalafil with any high blood pressure medicine.
Alcohol
While taking tadalafil, it is not recommended that you drink large quantities of alcohol. Doing so may cause a decrease in blood pressure, an increase in heart rate, dizziness, or headache.
Alpha Blockers
In previous research studies, when alpha blockers and tadalafil were used at the same time for people with benign prostatic hyperplasia (BPH) or high blood pressure, blood pressure decreased. Also, some people experienced lightheadedness, dizziness, or fainting when standing from either a sitting position or lying down. Your doctor may recommend a lower dosage of tadalafil if you are taking an alpha blocker.
Ritonavir
Taking both tadalafil and ritonavir or indinavir (which are HIV protease inhibitors) may cause your body to metabolize the medications differently than intended. People taking these medicines with tadalafil are more likely to experience a decrease in blood pressure, fainting, or prolonged erection. If you are taking both types of medication, it is important that you take tadalafil no more often than every 72 hours, with a maximum dose of tadalafil 10 mg. Additionally, other HIV protease inhibitors (which have not been studied with tadalafil yet) may cause a similar reaction.
Antifungals (Nizoral, Diflucan, or Sporanox)
Taking both antifungals and tadalafil together may cause your body to metabolize the medicines differently than intended. This can result in increased levels of tadalafil in the blood. People taking these medicines together should be prescribed a maximum tadalafil dosage of 10 mg, and should not take more than one tadalafil tablet every 72 hours.
Erythromycin
Taking both erythromycin and tadalafil may cause your body to metabolize the medicines differently than intended. Your doctor may choose to make necessary dosing adjustments.
Grapefruit Juice
Drinking grapefruit juice may affect how your body metabolizes tadalafil. Your healthcare provider may choose to adjust your dosage.
Nitrates
If you are taking nitrates, you should not use tadalafil. This includes using recreational drugs called “poppers,” which can contain amyl nitrate or butyl nitrate.
Theophylline
Taking theophylline and tadalafil may cause a slight increase in heart rate. Your doctor may choose to make necessary dosing adjustments.
There are a number of medications that tadalafil can potentially interact with. It is possible that not all drug interactions with tadalafil were discussed is this article. Therefore, you should talk with your doctor about the drug interactions that may apply to you.
Source: http://men.emedtv.com/tadalafil/drug-interactions-with-tadalafil-p3.html
